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Protease Inhibitors (PIs)

PIs, as their name suggests, work by blocking the activity of proteases. Proteases are the viral enzymes responsible for accurately cleaving newly formed viral proteins that result from translation of viral mRNA. Therefore, PIs prevent the formation of viral proteins, resulting in a paucity of available proteins for the formation of new copies of HIV.

FDA-approved PIs

For additional information about GlaxoSmithKline HIV products, please click on "Important Safety Information/Indications."

Brand name

Generic name

Pharmaceutical company

Prescribing Information for GlaxoSmithKline products

Aptivus®*

tipranavir

Boehringer Ingelheim

Crixivan®*

indinavir sulfate

Merck & Co.

Invirase®*

saquinavir mesylate

Hoffmann-La Roche

Kaletra®*

lopinavir / ritonavir

Abbott Laboratories

Lexiva®

fosamprenavir calcium

GlaxoSmithKline

Prescribing Information

Norvir®*

ritonavir

Abbott Laboratories

Prezista™*

darunavir

Tibotec

Reyataz®*

atazanavir sulfate

Bristol-Myers Squibb

Viracept®*

nelfinavir mesylate

Pfizer

*The brands listed above are trademarks of their respective owners and are not trademarks of The GlaxoSmithKline Group of Companies. The makers of these brands are not affiliated with and do not endorse GlaxoSmithKline or its products.

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