The first drug to treat HIV was approved by the FDA in 1987. This drug was seen as a breakthrough. Over time, this drug did not remain as effective in all people with HIV due to the development of viral resistance. As a result, researchers began experimenting with the use of 2- and 3-drug combinations, also called drug cocktails.
In 1991, a second anti-HIV drug was approved by the FDA, allowing healthcare providers to prescribe the first drug cocktail for HIV. Compared to the use of a single drug to treat HIV, the use of drug cocktails slowed the development of resistance to treatment. The success of drug cocktails resulted in a flurry of research that has led to the development of numerous types of drugs used today.
HAART is combination therapy that includes 3 or more anti-HIV drugs. Today, there are 5 different types of anti-HIV medicines available:
Each one works differently. The most common combination of drugs used in HAART today includes 2 NRTIs with 1 NNRTI or PI.
The use of HAART has led to an increase in survival among people with HIV. In fact, since the introduction of HAART in 1995, there has been a dramatic decline in deaths linked to HIV infection. Now that people with HIV are living longer, they need to consider other long-term conditions like diabetes, high blood pressure, and high cholesterol.